Cubs vs. White Sox odds, prediction, line: 2022 MLB picks, Saturday, May 28 best bets from proven model

Rivals square off when the Chicago Cubs (18-26) go on the road to play the Chicago White Sox (22-22) on Saturday afternoon in a 2022 Crosstown Classic matchup. Both teams look to bounce back after they were handed a loss in their last matchups. The Cubs are 4-6 in their last 10 games. Meanwhile, the White Sox went 5-5 over the past 10 outings. Keegan Thompson (4-0, 1.54 ERA) gets the start for the Cubs. Johnny Cueto (0-0, 0.00 ERA) is on the hill for the White Sox.

First pitch is set for 7:15 p.m. ET. Caesars Sportsbook lists the White Sox at -140 on the money line (risk $140 to win $100) in the latest Cubs vs. White Sox odds. The over-under for total runs is set at eight. Before making any White Sox vs. Cubs picks, you need to see the MLB predictions and betting advice from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times and it is off to a strong start to the 2022 season. It’s on a 41-30 roll on top-rated MLB money-line picks through seven weeks, returning almost $600 for $100 players. Anyone following it has seen huge returns.

Now, the model has set its sights on Cubs vs. White Sox and just locked in its picks and MLB predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for White Sox vs. Cubs:

  • Cubs vs. White Sox money line: White Sox -140, Cubs +120
  • Cubs vs. White Sox run line: White Sox -1.5 (-140)
  • Cubs vs. White Sox over-under: 8 runs
  • Cubs vs. White Sox tickets: See tickets at StubHub
  • CHC: Over is 6-1 in Cubs’ last seven overall
  • CHW: White Sox are 5-0 in their last five interleague home games

Why you should back the White Sox

Shortstop Tim Anderson is a sensational athlete in the infield for Chicago. Anderson has amazing bat control and sound pitch recognition. He knows how to consistently get on base while also owning a terrific throwing arm on defense. Anderson is second in the majors in batting average (.363) while leading the team in hits (57) and on-base percentage (.401).

Designated hitter Andrew Vaughn is a power hitter whose patient at the dish. Vaughn has a compact and controlled swing that allows him to drive the ball all across the yard. The 24-year-old has the ability to consistently produce home runs and extra-base hits. Vaughn has a batting average of .292 with five home runs and 19 RBIs. He has recorded two-plus hits in three of his last four games. 

Why you should back the Cubs

Shortstop Nico Hoerner is a natural hitter with a great eye. Hoerner can consistently make contact and hit for a solid average. The 25-year-old has amazing instincts on the defensive end and knows how to make the correct read. Hoerner’s batting average is .277 with three home runs and 13 RBIs.

Third baseman Patrick Wisdom plays sound defense in the corner and delivers darts across the diamond. The 30-year-old is inconsistent at the dish but has displayed home-run power and run-producing qualities. Wisdom is first on the team in home runs (10) along with 23 RBIs. On May 24, he was 2-for-5 with two singles and two runs scored. 

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How to make White Sox vs. Cubs picks

SportsLine’s model is leaning over on the total, projecting 8.8 combined runs. It also says one side of the money line has all the value. You can only get the MLB model’s picks at SportsLine.

So who wins Cubs vs. White Sox? And which side has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.  

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